RESVERATROL AND LORATADINE EFFECTS ON OXIDATIVE STRESS INDUCED BY EXPERIMENTAL INFLAMMATION
| dc.contributor.author | Daniela-Rodica MITREA | |
| dc.contributor.author | Simona CLICHICI | |
| dc.contributor.author | Adriana FILIP | |
| dc.contributor.author | Diana OLTEANU | |
| dc.contributor.author | Ioana BÂLDEA | |
| dc.contributor.author | Remus MOLDOVAN | |
| dc.contributor.author | Nicoleta DECEA | |
| dc.contributor.author | Oana-Alina HOTEIUC | |
| dc.date.accessioned | 2024-10-16T17:22:38Z | |
| dc.date.issued | 2017-03 | |
| dc.description | STUDIA UBB CHEMIA, LXII, 1, 2017 (p. 89-100), DOI:10.24193/subbchem.2017.1.07 Daniela-Rodica MITREA Department of Physiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania *Corresponding author: rdmitrea@yahoo.co.uk Simona CLICHICI Department of Physiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania https://orcid.org/0000-0002-0046-0803 Adriana FILIP Department of Physiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania https://orcid.org/0000-0002-7447-4925 Diana OLTEANU Department of Physiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania https://orcid.org/0000-0002-3034-3659 Ioana BÂLDEA Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania https://orcid.org/0000-0003-4046-7310 Remus MOLDOVAN Department of Physiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania https://orcid.org/0000-0002-4441-7030 Nicoleta DECEA Department of Physiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania https://orcid.org/0000-0002-8707-957X Oana-Alina HOTEIUC Department of Physiology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania https://orcid.org/0000-0002-3468-2922 | |
| dc.description.abstract | Resveratrol is a polyphenol with important antioxidant and anti-inflammatory roles. Loratadine, as a selective inverse-agonist of peripheral receptor H1, is described as an anti-allergic substance with potential anti-inflammatory effects. We aimed to assess the protective capacity of loratadine against oxidative stress produced by inflammation with carrageenan in comparison with a well-known antioxidant compound, resveratrol. Our results showed that resveratrol and loratadine had no protective anti-inflammatory effects in inflamed skin. As expected, resveratrol had antioxidant effects in serum and in liver. Loratadine developed oxidative stress in tegument and serum. In this experimental model, our results do not sustain the initial hypothesis that loratadine could have a protective effect in inflammation, and, in the contrary, is capable of increasing it, by producing an oxidative stress. | |
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| dc.identifier.issn | 1224-7154 | |
| dc.identifier.issn | (online): 2065-9520 | |
| dc.identifier.uri | http://dspace.chem.ubbcluj.ro:4000/handle/20.500.14637/12 | |
| dc.language.iso | en | |
| dc.publisher | STUDIA UBB CHEMIA. Published by Babeş-Bolyai University | |
| dc.relation.ispartofseries | STUDIA UBB CHEMIA, LXII, 1, 2017 (p. 89-100), DOI:10.24193/subbchem.2017.1.07 | |
| dc.subject | antioxidants | |
| dc.subject | inflammation | |
| dc.subject | loratadine | |
| dc.subject | oxidative stress | |
| dc.subject | resveratrol | |
| dc.title | RESVERATROL AND LORATADINE EFFECTS ON OXIDATIVE STRESS INDUCED BY EXPERIMENTAL INFLAMMATION | |
| dc.type | Article |