PREPARATION, CHARACTERIZATION, AND EVALUATION OF THE PHOTOCATALYTIC EFFECT OF α-Fe₂O₃/SAPO-34 IN THE ELIMINATION PROCESS OF THE ANTI-CANCER DRUG DOXORUBICIN FROM AQUEOUS SOLUTION
Date
2017-03-30
Authors
Mohammad Hosein BIGTAN
Kazem MAHANPOOR
Journal Title
Journal ISSN
Volume Title
Publisher
STUDIA UBB CHEMIA. Published by Babeş-Bolyai University
Abstract
In this investigation, α-Fe₂O₃/SAPO-34 nano-structure were synthesized and characterized by XRD, SEM and FT-IR techniques. Morphologically, the shape of α-Fe₂O₃/SAPO-34 nanoparticles is close to spherical nanoparticles with an average particle size of 93 nm determined by Debye-Scherrer equation. The photocatalytic activity of α-Fe₂O₃/SAPO-34 nanostructure was investigated through the degradation of doxorubicin, an anti-cancer drug using a batch reactor under UV-C irradiation and H₂O₂ as oxidant. The effect of various factors including drug concentration, catalyst dosage, pH and H₂O₂ concentration on the degradation yield were investigated. The results showed that optimum conditions were: Initial concentration of DOX = 20 ppm, pH = 8, amount of α-Fe₂O₃/SAPO-34 = 150 mg/L, and H₂O₂ concentration 4 mol/L.
Description
STUDIA UBB CHEMIA, LXII, 1, 2017 (p. 203-212), DOI:10.24193/subbchem.2017.1.18
Mohammad Hosein BIGTAN
Department of Chemistry, Arak Branch, Islamic Azad University, Arak, Iran
Kazem MAHANPOOR
Department of Chemistry, Arak Branch, Islamic Azad University, Arak, Iran
*Corresponding author: k-mahanpoor@iau-arak.ac.ir
Keywords
Doxorubicin, Photocatalytic degradation, α-Fe<sub>2</sub>O<sub>3</sub>/SAPO-34, Nanocatalyst
Citation
A. Grimm, K. Madduri, A. Ali, C.R. Hutchinson, Gene, 1994, 151, 1.
A. Brayfield, ed. "Doxorubicin". Martindale: The Complete Drug Reference. Pharmaceutical Press, 2013.
S.N. Mahnik, K. Lenz, N. Weissenbacher, R.M. Mader, M. Fuerhacker, Chemosphere, 2007, 66, 30.
Z. Chen, G. Park, P. Herckes, P. Westerhoff, J. Adv. Oxid. Technol., 2008, 11, 254.
J. Hirose, F. Kondo, T. Nakano, T. Kobayashi, N. Hiro, Y. Ando, H. Takenaka, K. Sano, Chemosphere, 2005, 60, 1018.
C.A. Somensi, E.L. Simionatto, J.B. Dalmarco, P. Gaspareto, C.M. Radetski, J. Environ. Sci. Health A., 2012, 47, 1543.
X.H. Wang, A.Y.C. Lin, Environ. Pollut., 2014, 186, 203.
N. De la Cruz, J. Giménez, S. Esplugas, D. Grandjean, L.F. De Alencastro, C. Pulgarín, Water Res., 2012, 46, 1947.
A. Chatzitakis, C. Berberidou, I. Paspaltsis, G. Kyriakou, T. Sklaviadis, I. Poulios, Water Res., 2008, 42, 386.
E. Aghaei, M. Haghighi, Powder Technol., 2015, 269, 358.
M. Nikazar, K. Gholivand, K. Mahanpoor, Kinet. Catal., 2007, 48, 214.
J.M. Wu, T.W. Zhang, J. Photochem. Photobiol. A., 2004, 162, 171.
E. Pipelzadeh, A.A. Babaluo, M. Haghighi, A. Tavakoli, M. Valizadeh Derakhshan, A. Karimzadeh Behnami, Chem. Eng. J., 2009, 155, 660.
Y.X. Yang, M.L. Liu, H. Zhu, Y.R. Chen, G.J. Mu, X.N. Liu, Y.Q. Jia, J. Magn. Magn. Mater., 2008, 320, L132.
N.K. Chaudhari, H.C. Kim, D. Son, J.-S. Yu, Cryst. Eng. Comm., 2009, 11, 2264.
E. Aghaei, M. Haghighi, Powder Technol., 2015, 269, 358.